Rashmi Ramesh

Citation

Thesis Title
Unravelling the dynamics of protein- protein interactions in the Gcn2 signal transduction pathway

Read article at Massey Research Online:

Protein-protein interactions are vital to most cellular processes. In eukaryotic cells, protein synthesis is regulated for a rapid response to various types of stress, and this involves several protein-protein interactions. One regulatory pathway that enables cells to cope with stress caused due to nutrient limitation is called the general amino acid control (GAAC) in yeast. The key molecule in GAAC is Gcn2, the stress sensor protein. Gcn2 is also implicated in human diseases such as cancer, making it a necessity to understand the regulatory aspects of this molecule. Ms Ramesh hypothesised that Gcn2 is regulated by many proteins and protein-protein interactions in a space and time dependent manner. Using in vivo and in vitro approaches she unravelled the finer details of how the proteins Yih1, eEF1A and Actin regulate Gcn2. Her research contributes to a better understanding of how Gcn2 is regulated within the cell

Supervisors
Associate Professor Evelyn Sattlegger
Distinguished Professor Paul Rainey